PPB can return after it is originally thought to have been eliminated. It can return in the chest or at sites elsewhere in the body (see Does PPB Spread?). If surgery was the only initial treatment, the recurrent disease may be treated again by surgery, and chemotherapy and radiation are likely to be added. If surgery, radiation and chemotherapy have been used initially, the return of disease is discouraging, but aggressive and innovative treatments may be recommended by the child’s oncology team. For example, the disease may be susceptible to different chemotherapy drugs or to the same drugs given at higher doses.