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The International Pleuropulmonary Blastoma Registry
The International Pleuropulmonary Blastoma Registry
Pathology
Recommended Path Studies

Immunohistochemistry and genetic analysis tend to add little to the impression obtained by routine histology. PPB commonly shows staining for desmin and myogenin in areas of obvious rhabdomyosarcomatous differentiation as well as in a subset of the primitive subepithelial cells. S100 protein is typically limited to the cartilaginous nodules. Cytokeratin highlights the benign lining mesothelium/epithelium but is negative in the tumor cells.

Pathologists are asked to consider sending tissue to the PPB Registry Tissue Bank. For details, see Tissue Bank

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Data and recommendations on this site are conscientiously presented but some are unpublished observations and have not undergone peer review. Consultation with the Registry is encouraged to clarify any topics. The International PPB Registry advises caution in the citation of website information.
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